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Demo

Variant evidence lookup

Aggregated across CIViC, ClinVar, ClinicalTrials.gov, openFDA, and CPIC. Tier per Li et al. (2017) framework, paraphrased.

Reference data only, not for clinical use. UNMIRI is not a medical device. Do not paste patient identifiers.
Try an example

Enter a variant in any one of the three variant fields. A gene symbol on its own does not identify a variant.

Try a worked example:

EGFR L858R · lung adenocarcinoma
Textbook positive. FDA-approved CDx plus active trials.
BRAF V600E · melanoma
BRAF/MEK combo evidence, vemurafenib lineage.
BRCA1 · ovarian cancer
PARP inhibitor pathway, ACMG/AMP framework.

Pre-built variant references

Skip the lookup and read a full evidence cheat sheet for these high-traffic variants: