Demo

Variant evidence lookup

Aggregated across CIViC, ClinVar, ClinicalTrials.gov, openFDA, and CPIC. Tier per Li et al. (2017) framework, paraphrased.

Reference data only, not for clinical use. UNMIRI is not a medical device. Do not paste patient identifiers.

Try an example

Try a worked example:

EGFR L858R · lung adenocarcinoma

Textbook positive. FDA-approved CDx plus active trials.

BRAF V600E · melanoma

BRAF/MEK combo evidence, vemurafenib lineage.

BRCA1 · ovarian cancer

PARP inhibitor pathway, ACMG/AMP framework.

Pre-built variant references

Skip the lookup and read a full evidence cheat sheet for these high-traffic variants: