Open clinical references
Variant cheat sheets
One-page references for the variants oncologists and pathologists encounter most often. AMP/ASCO/CAP 2017 tiers, FDA-approved companion diagnostics, and resistance pathways. Citations point to CIViC, ClinVar, ClinicalTrials.gov, openFDA, and primary literature you can verify yourself.
Free. No signup. Decision-support aid only — not a CAP/CLIA-validated diagnostic.
- Lung
EGFR mutations in NSCLC
Activating mutations (L858R, exon 19 del, exon 20 ins, T790M), first-line targeted therapy by mutation class, resistance pathways, FDA-approved companion diagnostics.
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- Melanoma
BRAF mutations in melanoma
V600 vs Class II/III BRAF, doublet and triplet combinations, when single-agent BRAF inhibition is harmful, FDA-approved companion diagnostics.
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- Lung
KRAS G12C in NSCLC
Sotorasib and adagrasib post-platinum, resistance via secondary KRAS mutations and bypass amplifications, STK11/KEAP1 co-mutation modifiers, ICI combo trial readouts to watch.
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More coming
The reference set expands as we add panels to UNMIRI's coverage. Next on deck: ALK rearrangements in NSCLC, HER2 amplification across solid tumors, BRCA1/2 in ovarian and prostate. Want one specific to your workflow? Tell us.
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