Demo

Case studies

Each writeup walks through one synthetic sample end-to-end: source PDF, canonical schema, evidence join, CDS routing. Real reports never appear here.

Educational use only. Synthetic data, demonstration only. Not a medical device. Not for unsupervised clinical decision-making.

EGFR L858R in metastatic NSCLC
Foundation Medicine F1CDx, variant call, AMP/ASCO/CAP I-A, osimertinib FDA CDx, 47 matching trials.
About 4 min read
Pathogenic BRCA1 in high-grade serous ovarian
Caris MI Profile, BRCA1 frameshift, I-A, olaparib + niraparib, HRD-positive cohort match.
About 5 min read
Tumor-agnostic TMB-high + MSI-H signal
Tempus xT, TMB 21 mut/Mb, MSI-H, pembrolizumab tumor-agnostic indication, vendor-only reporting differences.
About 5 min read

Browse the underlying reference content

Each case study points to the variant cheat sheet that backs the clinical decision logic.

17 variant cheat sheets →CPIC pharmacogenomics →Trial-by-gene index →Open FHIR Genomics schema →